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A genetic pathway composed of Sox14 and Mical governs severing of dendrites during pruning
submitted by sarwar 9 days ago (via feeds.nature.com)
Certain Drosophila dendrites undergo major remodeling during metamorphosis. This study shows that the severing of larval dendrites, which is the first step of remodeling, depends on the upregulation of the cytoskeleton-binding protein Mical by the transcription factor Sox14.
 
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Nardilysin regulates axonal maturation and myelination in the central and peripheral nervous system
submitted by sarwar 9 days ago (via feeds.nature.com)
Nardilysin (NRDc) enhances the shedding of ectodomains from neuronal membrane proteins. The null mutant described here reveals that nardilysin is necessary for myelination in both central and peripheral nervous system.
 
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Vascular niche factor PEDF modulates Notch-dependent stemness in the adult subependymal zone
submitted by sarwar 9 days ago (via feeds.nature.com)
Notch signaling is essential for the maintenance of adult neural stem cells in vivo. Here, Andreu-Agulló and colleagues show that PEDF, released from endothelial cells, enhances Notch signaling in the mouse subependymal zone by inactivating a repressor of Notch target genes.
 
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Adult generation of glutamatergic olfactory bulb interneurons
submitted by sarwar 9 days ago (via feeds.nature.com)
Neural stem cells in the adult mouse SVZ are thought to only generate GABAergic olfactory bulb interneurons. This study reports that a dorsal region of the adult SVZ gives rise to a glutamatergic type of olfactory bulb neurons. These newborn glutamatergic neurons can be diverted to migrate into the cortex towards an injury, possibly contributing to repair.
 
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